聚环芳暴露与围产期焦虑症状的关联
Hualong Zhen1, Yunfei Jia1, Beibei Zhu1,2,3
1School of Public Health, Anhui Medical University, Hefei, 230032, China.
BMC public health
|April 2, 2025
概括
暴露于多环芳 (PAHs) 与增加围产期焦虑有关. 怀孕期间尿液中特定PAH代谢物的较高水平与产前和产后焦虑症状的更大风险相关.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 生殖健康 生殖健康
背景情况:
- 多环芳 (PAH) 是具有可疑神经毒性作用的环境污染物.
- 新出现的证据表明,PAH暴露与神经和心理状况之间存在潜在的联系.
研究的目的:
- 调查暴露于多环芳 (PAH) 和围产期焦虑症状的发展之间的关联.
- 量化尿中PAH代谢物,并评估它们与怀孕和产后焦虑的关系.
主要方法:
- 一项涉及中国合肥市642名孕妇的病例控制研究,从2020年4月至2021年7月.
- 评估焦虑症状使用7项通用焦虑障碍量表和量化12个尿液中氧化PAH代谢物.
- 使用后勤回归和贝叶斯内核机器回归 (BKMR) 进行分析,以确定PAH暴露和围产期焦虑之间的关联.
主要成果:
- 在尿中PAH代谢物水平和产前焦虑之间观察到显著的剂量反应关系.
- 对2-OHNA,9-OHFLU,OHFLU,2-OHDBF和OH-PAHs的高暴露率与增加产前焦虑的几率有关.
- 产前尿液中2-OHFLU和OHFLU度的升高与产后焦虑症状的风险更高有关.
结论:
- 这项研究强调了多环芳 (PAH) 暴露与围产期焦虑症状之间的显著积极关联.
- 研究结果表明,暴露于PAH可能是孕期和产后焦虑的一个因素.
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