在患有间歇性肺病的人群中,身体构成,最大健康状况和次最大运动功能
Owen W Tomlinson1,2,3, Anna Duckworth2,3, Laura Markham2,3
1Department of Public Health and Sport Science, Faculty of Health and Life Science, University of Exeter, Heavitree Road, Exeter, EX1 2LU, UK.
在间歇性肺病 (ILD) 中,心肺运动测试 (CPET) 显示,女性的峰值氧气吸收 (VO2峰值) 较高,当通过无脂肪质量 (FFM) 进行缩放时. 氧吸收效率高原 (OUEP) 成为ILD患者有前途的亚最大标志物.
科学领域:
- 肺部医学 肺部医学
- 运动生理学 运动生理学
- 心血管健康 呼吸系统健康
背景情况:
- 心肺运动测试 (CPET) 是评估间歇性肺病 (ILD) 的一个有价值的工具.
- 传统的CPET分析通常使用身体质量进行缩放,但无脂肪质量 (FFM) 可能更准确地反映了运动期间的代谢活动.
- 确定可靠的亚最大限度运动参数至关重要,因为ILD患者可能并不总是达到最大限度的运动.
研究的目的:
- 通过FFM在ILD患者中使用不同的技术,评估缩放峰值氧气吸收 (VO2峰值) 的有效性.
- 描述氧气吸收效率坡度 (OUES) 和氧气吸收效率高原 (OUEP) 作为ILD中的潜在次最大运动参数.
- 调查这些参数与肺功能测量之间的关系.
主要方法:
- 在ILD参与者中评估了身体成分和CPET.
- 使用比率标准和全米技术相对于体重和FFM进行VO2峰值缩放.
- 用皮尔森的相关性和科恩的卡帕来评估OUES,OUEP,肺功能和VO2峰值之间的一致性.
主要成果:
- 在VO2峰值中有效调整为体型的比例标准缩放.
- 当扩展到FFM时,女性的VO2峰值明显高于男性.
- OUEP与DLCO有显著的正相关性,与VO2peak有适度的相关性.
结论:
- 比例标准缩放足以使ILD中的VO2峰值正常化.
- 经FFM调整后的VO2峰值在女性中显示出更高的值,突出显示了身体构成的重要性.
- OUEP被确定为ILD的潜在,临床相关的亚最大标志物,值得进一步研究.
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