来自种子的功能化新型碳点,用于可持续绿色EDOXABAN量化
Rasha Th El-Eryan1, Mona S Elshahed1, Dalia Mohamed1
1Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt.
BMC chemistry
|April 2, 2025
概括
从种子中合成的绿色碳点提供了一种敏感的光探针,用于检测非光药物EDO. 这种环保的方法适用于药品质量控制.
科学领域:
- 绿色化学与可持续发展
- 材料科学和纳米技术
- 分析化学是一种分析化学.
背景情况:
- 全球越来越多的环境问题意识推动了"绿色"化学方法的采用.
- 新的绿色碳点 (CD) 正在从自然资源中开发,用于可持续的应用.
- 埃多克萨班托西酸 (EDO) 是一种非光药物,需要敏感的检测方法.
研究的目的:
- 从回收的胡种子中合成新的绿色碳点 (CD).
- 开发一种灵敏的光探针,用于确定埃多克萨班托西拉酸水合物 (EDO).
- 评估开发的制药分析方法的绿色性和适用性.
主要方法:
- 绿色碳点 (CD) 用微波辅助和热分解方法从种子中合成.
- 使用内部波器效应的光火法用于EDO的确定.
- 对CD的表征涉及UV-vis,光谱,TEM和XPS等技术.
- 方法验证遵循ICH指导方针,包括在市场上销售的EDO片上进行的恢复研究.
主要成果:
- 合成的CD在EDO的存在下表现出光火,从而可以进行定量测定.
- 该方法实现了EDO的检测极限低至0.22μg/mL.
- 对于药物配方中的EDO,获得了高回收率 (98.79% - 99.77%).
- 使用蓝色适用度指数,CPAMI和分析生态尺度来评估该方法的绿色性.
结论:
- 从种子中成功合成了新的,具有成本效益和灵敏的光CD.
- 开发的方法提供了一种可靠的,绿色的方法,用于药品中Edoxaban托西拉酸的常规质量控制.
- 该研究强调了植物衍生碳点在分析化学和可持续实践中的潜力.
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