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集成IL13RA2的基因工程小鼠模型允许CAR T细胞向儿科高度质瘤

M Seblani1,2, M Zannikou2,3, J T Duffy2,3

  • 1Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

Acta neuropathologica communications
|April 2, 2025
PubMed
概括

研究人员开发了一种针对儿科高度质瘤 (pHGG) 和扩散中线质瘤 (pDMG) 的新免疫能力小鼠模型. 这种模型成功地证明了接13受体α2 (IL13RA2) 向免疫治疗的疗效,改善了生存率.

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