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睡眠障碍,轮班工作和劳动年龄成年人的表观遗传衰老:来自年轻芬兰人的研究结果
Ida Autio1, Aino Saarinen2, Saara Marttila3,4,5
1Department of Psychology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.
Clinical epigenetics
|April 2, 2025
概括
阻塞性睡眠呼吸暂停症状显著加速表观遗传衰老. 轮班工作改变了睡眠障碍和成人表观遗传衰老之间的关系.
科学领域:
- 睡眠科学 睡眠科学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老的研究研究.
背景情况:
- 睡眠障碍会对健康产生负面影响.
- 对睡眠障碍对表观遗传衰老的影响的理解有限.
- 调查失眠,睡眠呼吸暂停,睡眠不足,昼夜节律和表观遗传衰老之间的联系,以及轮班工作的缓解作用.
研究的目的:
- 为了确定失眠,阻塞性睡眠呼吸暂停 (OSA),睡眠剥夺和昼夜节律延迟是否与表观遗传衰老有关.
- 评估多年轮班工作是否缓和了这些关联.
主要方法:
- 利用了芬兰年轻人的数据 (n=1618).
- 使用多个表观遗传钟 (例如,AgeDevGrim,DunedinPACE) 来测量表观遗传衰老.
- 评估睡眠使用验证的问卷,控制性,吸烟和心血管健康等共变量.
主要成果:
- 阻塞性睡眠呼吸暂停症状显示出与加速表观遗传衰老有着一致的联系 (AgeDevGrim,DunedinPACE).
- 失眠,睡眠不足和轮班工作的持续时间在同变量调整后与表观遗传衰老没有直接关联.
- 发现了相互作用:在非轮班工人中,失眠和睡眠剥夺加速了表观遗传衰老 (AgeDevGrim);睡眠剥夺与长期轮班工作相结合,增加了表观遗传衰老速度 (DunedinPACE).
结论:
- 阻塞性睡眠呼吸暂停症状与加速表观遗传衰老密切相关,独立于健康和社会经济因素.
- 轮班工作在睡眠障碍如何影响劳动年龄成人表观遗传衰老方面发挥着重要作用.
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