相关实验视频

Updated: May 16, 2025

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Author Spotlight: Rabies-Specific Antibody Isotypes Detection in Sera or Cerebral Spinal Fluid Using an IFA Test

Published on: January 19, 2024

在使用长效注射PrEP的人群中实践HIVRNA和抗原/抗体测试

Weiming Zhu¹, Kevin Delaney¹, Ya-Lin A Huang¹

¹Division of HIV Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

|April 3, 2025

概括

使用卡博特格拉维尔 (CAB-LA) 的注射性暴露前预防 (PrEP) 可能导致艾滋病毒检测结果不清晰. 这项研究在早期CAB-LA用户中发现了突破性HIV或LEVI综合征的低发病率,这表明RNA测试是可以做到的.

科学领域:

传染性疾病传染性疾病
病毒学病毒学
公共卫生公共卫生

背景情况:

长效可注射卡博特格拉维尔 (CAB-LA) 用于艾滋病毒暴露前预防 (PrEP).
如果在治疗期间获得艾滋病毒,HIV检测可能会在CAB-LA用户中产生模两可的结果.
目前的指导方针建议HIV抗原/抗体 (Ag/Ab) 和RNA测试用于CAB-LA启动和随访.

研究的目的:

评估CAB-LA PrEP使用者的HIV检测使用情况.
估计突破性艾滋病毒感染和长效早期病毒抑制 (LEVI) 综合征的发生率.
为了评估测试一致性和准确性.

主要方法:

一项队列研究分析了CAB-LA PrEP用户的HealthVerity数据库.
识别并裁决了HIV Ag/Ab和RNA测试,结果呈阳性.
突破性艾滋病毒和LEVI综合征的估计发病率,以及探索的测试协议.

主要成果:

在384名CAB-LA PrEP使用者中,随访时间中位数为4.2个月,观察到一个不一致的Ag/Ab(-) RNA(+) 和一个不一致的Ag/Ab(+) RNA(-) 对.
在四个阳性测试中,一个是启动前的HIV获取,一个可能是错误的RNA阳性,一个可能是错误的Ag/Ab阳性,一个是不确定的.
没有确认突破性艾滋病毒感染或LEVI综合征病例.

结论:

突破性艾滋病毒感染或LEVI综合征的发病率在CAB-LA PrEP使用的最初3-7个月内很低.
需要进一步评估HIV RNA测试对监测CAB-LA PrEP的附加值.

关键词:

在CAB-LA中使用.艾滋病毒RNA测试是对艾滋病毒RNA的测试.这就是为什么PrEP是PrEP.突破性感染的突破性感染

更多相关视频

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

相关概念视频

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...