在第一次初级黑色素瘤之后发展第二种初级癌症的绝对风险:澳大利亚基于人口的队列研究
Yuan Ni1,2, Caroline G Watts1,3, Alexander H R Varey2,4,5
1The Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.
American journal of epidemiology
|April 3, 2025
概括
被诊断出第一种原发性黑色素瘤的个体,患第二种原发性癌症的风险为23.7%. 另一种黑色素瘤是最常见的第二种癌症,强调需要持续的皮肤监测.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 评估后续原发性癌症的绝对风险对于患者管理和教育至关重要.
- 黑色素瘤幸存者需要特定的监测策略,因为潜在的风险,新的原发性恶性瘤.
研究的目的:
- 调查第一个初级黑色素瘤诊断后发展第二种初级癌症的累积发病率和风险因素.
- 为了区分第二种黑色素瘤的风险与这个队列中的其他第二种原发性癌症.
主要方法:
- 在澳大利亚新南威尔士州 (1982-2019) 诊断出第一个原发性黑色素瘤的154,695人中进行了基于人口的队列研究.
- 癌症发病率和生命状况的随访时间平均为7.0年.
- 采用细灰竞争风险模型来分析数据,并考虑死亡率.
主要成果:
- 总共有23.7%的个人在第一次黑色素瘤诊断后出现了第二次原发性癌症.
- 第二次原发性黑色素瘤 (侵袭性或现场) 发生在12.7% (平均5年风险:7.6%) 的患者中.
- 其他常见的第二次原发性癌症包括前列腺 (2.8%男性特异性),乳腺 (0.7%女性特异性) 和结肠 (0.6%).
结论:
- 在初始黑色素瘤诊断后,最常见的第二种原发性癌症是另一种黑色素瘤.
- 长期的,勤奋的皮肤监测对于黑色素瘤患者至关重要,即使最初的瘤复发风险低.
- 了解这些风险可以为个性化的患者随访和教育策略提供信息.
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