在休息状态下改变大脑行为关联是潜在的精神病风险标志物
Leonardo Fazio1, Giuseppe Stolfa2, Roberta Passiatore2,3
1Department of Medicine and Surgery, LUM University, Casamassima, Bari, 70010, Italy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|April 3, 2025
概括
这项研究揭示了精神病中大脑行为连接的改变. 一个特定的大脑电路.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 精神病中的认知缺陷和神经成像变化可能表明大脑行为相互作用受损.
- 了解这些跨精神病阶段的相互作用对于识别生物标志物至关重要.
研究的目的:
- 研究神经类型对照 (NC),慢性精神病患者 (PSY) 和患有下值精神病症状 (STPS) 个体的认知功能和功能性大脑连接之间的关联.
- 为了识别可复制的大脑行为标记在精神病的不同阶段.
主要方法:
- 利用了来自多个队伍的1203名参与者的静止状态功能磁共振成像 (fMRI) 数据.
- 应用基于图形连接的方法来分析功能连接和认知表现 (威斯康星州卡片排序测试).
- 在NC中测试的关联和在PSY,STPS和外部队列中验证的结果.
主要成果:
- 在NC中,在右前额前额前 - 带 - 带电路的度中心度和威斯康星州卡片排序测试错误之间发现了正相关性.
- 在PSY和STPS中,这种关联逆转为负相关性,这一发现在队列中一致复制.
- 大脑行为关联的变化在精神病阶段是可复制的,而不是仅仅在中心性或认知方面的群体差异.
结论:
- 确定了与精神病中的特定电路相关的大脑行为关联的可复制性改变.
- 这种多式联运标记具有早期风险识别的潜力,需要进一步的纵向调查.
- 这些发现强调了图形连接在理解精神病的病理生理学的有用性.
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