在青少年精神病学住院患者中,精神病症状是否预测未来的精神病障碍? 一个长达17年的队列研究
Valentina Kieseppä1,2, Ulla Lång1,2,3, Colm Healy1,4
1Centre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Psychological medicine
|April 3, 2025
概括
青少年精神病医院住院患者面临高风险的精神分裂症谱系障碍 (SSD). 虽然全值精神病症状表明风险增加,但大多数SSD在没有这些初始症状的人中会发展.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 心理健康研究 心理健康研究
背景情况:
- 青少年精神病医院住院治疗与在成年后患上精神分裂症谱系障碍 (SSD) 的高风险有关.
- 青少年住院期间精神病症状对随后SSD发展的预测价值仍然不清楚.
研究的目的:
- 调查青少年精神病医院住院护理期间的精神病症状是否预测精神分裂症谱系障碍 (SSD) 在成年后的发展.
- 分析低值和高值精神病症状之间的关联,以及后来的SSD诊断.
主要方法:
- 一组由404名青少年 (年龄在13-17岁) 组成的队列,这些青少年被录取到芬兰的精神病医院住院护理,被跟踪到2023年6月.
- 用情绪障碍和精神分裂症表来评估精神病症状.
- 考克斯回归分析被用来确定基线精神病症状的预测值,用于随后使用国家卫生登记册进行SSD诊断.
主要成果:
- 28%的青少年报告了精神病症状 (17%的下值,11%的全值).
- 总体而言,23%的队列在随访时发展出SSD.
- 全值精神病症状与SSD风险增加有关 (HR=2.00),但小值症状没有 (HR=1.42).
- 最重要的是,83%的随后的SSD发生在没有临床精神病症状的患者中.
结论:
- 青少年精神病医院的住院患者有很大的风险,随着时间的推移,他们会患上SSD.
- 住院期间全值精神病症状预测SSD的风险更高,但敏感性低.
- 低于值的精神病症状并不能预测随后的SSD发展.
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