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相关概念视频

Allergic Drug Reactions01:27

Allergic Drug Reactions

800
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
800
Hypersensitivities01:30

Hypersensitivities

443
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
443
Cross-reactivity00:42

Cross-reactivity

30.9K
Overview
30.9K
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

6.3K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
6.3K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

1.4K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.4K
Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

8.2K
The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
8.2K

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相关实验视频

Updated: May 17, 2025

Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity

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[多重过敏性与多重不耐药性]

Eglė Janušonytė1, Dayana Jaramillo Loaiza2, Peter Jandus1

  • 1Service d'immunologie et allergologie, Hôpitaux universitaires de Genève, 1211 Genève 14.

Revue medicale suisse
|April 3, 2025
PubMed
概括
此摘要是机器生成的。

多种药物过敏综合征 (MDHS) 是罕见的,免疫介导,而多种药物不耐受综合征 (MDIS) 涉及非免疫反应. 这两种情况都影响了对几种无关药物反应的患者,但有不同的原因和症状.

科学领域:

  • 免疫学 免疫学 免疫学
  • 药理学 药理学是指药理学的学科.
  • 临床医学 临床医学

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