瘤原生微环境中的lncRNA:从威胁到治疗
Dipanjan Roy1, Bireswar Bhattacharya1, Rudra Chakravarti1
1Department of Natural Products, National Institute of Pharmaceutical Education and Research-Kolkata, Kolkata, India.
Frontiers in cell and developmental biology
|April 3, 2025
概括
长非编码RNAs (lncRNAs) 调节细胞过程,并与癌症的发展和进展有关. 它们的失调会影响细胞周期,使它们成为潜在的诊断标记物和治疗点.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 癌症研究 癌症研究
背景情况:
- 长非编码RNAs (lncRNAs) 是参与细胞功能的非蛋白质编码RNA分子 (>200核酸).
- lncRNAs参与细胞代谢,反应和病理生物学途径,影响自,炎症和亡.
- lncRNA表达的失调与细胞生命周期异常和疾病发展有关,特别是癌症.
研究的目的:
- 审查lncRNA转录组与基本细胞信号通路之间的相关性.
- 探索 lncRNA 介导的交叉声如何塑造致癌微环境.
- 突出 lncRNAs 在癌症增殖,进展和转移中的作用.
主要方法:
- 关于细胞过程中的lncRNA功能研究的文献综述.
- 对 lncRNA 参与癌症相关途径的分析,如细胞生长和上皮细胞-介质细胞过渡.
- 检查 lncRNAs作为疾病的诊断和预后标记.
主要成果:
- lncRNAs与细胞增殖有显著的关联,调节DNA复制,修复和蛋白质合成.
- lncRNA失调通过影响细胞周期和生存,促进癌症的发展.
- lncRNAs涉及癌症生长,上皮细胞-介质细胞过渡和转移.
结论:
- lncRNAs是细胞信号传递和瘤性微环境的关键调节者.
- lncRNAs代表了有希望的治疗点和癌症的诊断/预后生物标志物.
- 了解ncRNA与癌症的交叉交谈对于开发新型治疗策略至关重要.
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