血液炎症标志物与潜伏结核病感染之间的关联:来自NHANES 2011-2012年和转录基因数据的见解
Yang Liu1, Chunyan He2, He Zhao1
1Department of Laboratory Medicine Center, China-Japan Union Hospital of Jilin University, Changchun, China.
Frontiers in cellular and infection microbiology
|April 3, 2025
概括
较低的关键血液标志物水平,包括全身免疫炎症指数,与潜伏结核病感染有关. 这些发现可能会改善结核病的诊断和治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 潜伏性结核病感染 (LTBI) 影响全球四分之一的人口,有可能发展为活跃疾病.
- 血液炎症标志物在LTBI中没有得到充分研究,尽管它反映了全身炎症和免疫状态.
研究的目的:
- 调查血液炎症标志物和LTBI之间的关联.
- 探索LTBI患者的转录组变化.
主要方法:
- 分析了2011-2012年国家健康和营养检查调查的7042名参与者的数据.
- 使用QuantiFERON-TB Gold试验识别LTBI,并从全血细胞计数计算炎症标志物.
- 转录基因分析包括免疫细胞分析和基因表达分析.
主要成果:
- 患有LTBI的个体显著降低了系统性免疫炎症指数,中性粒细胞与淋巴细胞的比率,血小板与淋巴细胞的比率和单细胞与淋巴细胞的比率.
- 在调整了诸如年龄,性别,BMI,糖尿病和高血压等混因素后,关联仍然显著.
- 转录组数据显示,LTBI中T细胞活化升高,细胞分解活性增加,T细胞共抑制途径上调.
结论:
- 较低的全身免疫炎症指数和相关的血液学标志物独立与LTBI相关.
- 这些标记可能对识别和理解LTBI具有重要意义.
- 对这些标记物的进一步研究可以加强结核病的诊断和治疗策略.
更多相关视频
11:31Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
16.0K
07:42A Novel Microdissection Approach to Recovering Mycobacterium tuberculosis Specific Transcripts from Formalin Fixed Paraffin Embedded Lung Granulomas
Published on: June 5, 2014
8.0K
相关概念视频
Pulmonary Tuberculosis IV
125
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
125
Pulmonary Tuberculosis II
202
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
202
Pulmonary Tuberculosis III
277
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
277
Pulmonary Tuberculosis I
210
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
210
Non-LTR Retrotransposons
11.3K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.3K
