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相关概念视频

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions
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可生物降解的德克萨米他聚合物囊用于长期释放.

Avery Zheng1, Thomas Waterkotte1, Tilahun Debele1

  • 1Department of Chemical & Environmental Engineering, College of Engineering & Applied Sciences.

The Korean journal of chemical engineering
|April 3, 2025
PubMed
概括

可生物降解的聚合物囊为炎症性疾病提供持续的局部递送德甲 (Dex). 聚合物疏水性控制了Dex的释放速度,更多的疏水性聚合物显示药物释放速度较慢和有效的IL-6抑制在体外.

关键词:
它是生物降解的.德克萨米他是一种可以注射的植入物.长期药物输送 长期药物输送在PCL上,PCL是PCL.这就是为什么PLA PLA PLA.在 PLGA PLGA 中.

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科学领域:

  • 生物材料科学 生物材料科学
  • 药物输送系统 药物输送系统
  • 聚合物化学 聚合物化学

背景情况:

  • 炎症性疾病需要有效的局部药物输送.
  • 持续释放植入物比传统方法具有治疗优势.
  • 德克萨米他 (Dex) 是一种强大的抗炎性皮质类固醇.

研究的目的:

  • 开发和描述使用各种生物降解聚合物的持续释放甲甲 (Dex) 囊植入物.
  • 为了研究聚合物特性对Dex释放动态的影响.
  • 评估Dex植入物的体外治疗疗效和毒性.

主要方法:

  • 德克斯植入物的制造使用聚烯酸 (PCL),聚乳酸 (PLA) 和两种比例的聚乳酸-联合甘油酸 (PLGA).
  • 药物释放研究将数据与圆柱状储第一阶动力学模型相匹配.
  • 使用TNF-α刺激的人类静脉内皮细胞 (HUVECs) 进行体外疗效测试,以测量IL-6水平.

主要成果:

  • 药物释放率在聚合物之间差异很大,50:50 PLGA 释放速度最快,PCL 释放速度最慢.
  • 药物释放动力学与聚合物疏水性有很强的相关性;更多的疏水性聚合物导致水友性药物的释放速度较慢.
  • 与免费的Dex相比,Dex植入物有效地抑制了HUVEC中的IL-6水平,毒性最小.

结论:

  • 从可生物降解的植入物中释放德克萨米他的速度是可预测和可控制的,基于聚合物疏水性.
  • 持续释放的Dex植入物显示出在局部治疗炎症状况方面具有显著的潜力.
  • 这项研究为设计用于炎症疾病管理的优化聚合物药物输送系统提供了基础.