人类诱导的多能干细胞模型用于阿尔茨海默病的研究:一个图书法分析分析
Yuning Sun1,2, Zhilong Liu2, Zongbo Zhang3
1School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, China.
Frontiers in human neuroscience
|April 3, 2025
概括
这项研究分析了531篇关于人类诱导多能干细胞 (hiPSC) 的阿尔茨海默病 (AD) 模型的文章. 研究显示,这一趋势越来越多,美国领先,专注于炎症,微质和质,为新疗法铺平了道路.
科学领域:
- 生物医学研究生物医学研究
- 干细胞生物学 干细胞生物学
- 神经科学是一个神经科学.
背景情况:
- 阿尔茨海默病 (AD) 是导致痴呆的主要原因,没有足够的治疗方法.
- 现有的AD模型缺乏完全的人类生理和病理复制.
- 人类诱导的多能干细胞 (hiPSC) 技术为AD研究提供了一个有前途的途径.
研究的目的:
- 在阿尔茨海默病研究中对hiPSC技术应用进行文献计量分析.
- 确定该领域的关键趋势,有影响力的贡献者和研究缺口.
- 引导未来的研究方向,以开发有效的AD治疗方法.
主要方法:
- 来自Web of Science核心集合 (2010年1月至2024年6月) 的531篇文章的图书统计分析.
- 利用CiteSpace和VOSviewer分析作者身份,地理分布,期刊影响力和引用网络.
- 专注于与阿尔茨海默病的hiPSC模型相关的出版物.
主要成果:
- 14年来出版物的持续增长,美国和中国是主要贡献者.
- 马萨诸塞理工学院的Li-Huei Tsai被确定为一名杰出的研究人员.
- PLoS One被认为是最具影响力的期刊,研究趋势集中在炎症,星球细胞,微质细胞,ApoE和tau.
结论:
- 图书统计分析对于识别AD的研究差距和趋势至关重要.
- hiPSC模型对于理解AD的分子机制,特别是家族和零星形式至关重要.
- 这项研究为开发新型治疗策略和改善AD理解提供了基础.
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