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基于智能手机的Stroop测试,EncephalApp:诊断最小肝脑病变的最佳截止时间是什么?

Ryota Masuzaki¹, Hirofumi Kogure²

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, Tokyo 176-8610, Japan. masuzaki.ryota@nihon-u.ac.jp.

World journal of hepatology

|April 3, 2025

概括

智能手机Stroop测试 (EncephalApp) 显示出在非酒精性肝病中诊断最小肝脑病变的前景. 对于酒精与非酒精性肝硬化,需要不同的切断值.

科学领域:

肝病学肝病学是一种肝病学.
神经科学是一个神经科学.
医疗技术医疗技术医学技术

背景情况:

诊断最小肝脑病变 (MHE) 是一个挑战.
非酒精性肝病 (NALD) 影响认知功能.
需要用于肝脏疾病的非侵入性诊断工具.

研究的目的:

评估基于智能手机的Stroop测试EncephalApp的诊断准确性,用于非酒精性肝病患者的MHE.
在这个群体中确定EncephalApp的最佳切割值.
为了比较酒精性和非酒精性肝硬化之间的诊断效用.

主要方法:

160名患有非酒精性肝硬化症的患者被纳入.
进行了EncephalApp (智能手机Stroop测试) 的使用.
心理测量肝脏脑病症得分作为基准.

主要成果:

确定了最佳切断时间:>101.93s (关机时间) 和>205.86s (开启+关机时间).
灵敏度:0.84 (关机时间) 和0.90 (开启+关机时间).
具体性:0.77 (关机时间) 和0.71 (开启+关机时间).

结论:

EncephalApp在非酒精性肝病中展示了MHE的诊断能力.
对于非酒精患者和酒精性肝硬化患者,需要明确的切断值.
建议在更大的队列中进一步验证.

关键词:

与酒精有关的肝脏疾病肝硬化是肝硬化的一种疾病.与代谢功能障碍相关的肝病.最小的脑病变 - 最小的脑病变门口高血压的高血压.在Stroop测试中,

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Hepatic Encephalopathy

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic...