中性细胞外细胞陷与新辅助疗法的反应不佳和儿科骨髓瘤的生存率不佳有关
Szilvia Baron1,2, Yoav Binenbaum1,2,3, Ronny Maman1,2
1School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Frontiers in oncology
|April 3, 2025
概括
中性细胞细胞外陷 (NETs) 在骨髓瘤 (OS) 中升高,与化学疗法反应和存活率差异相关. 在诊断活检中高的NET负担表明OS患者的预后更差.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 骨髓瘤 (OS) 是儿童的一种具有挑战性的原发性骨癌.
- 中性细胞外细胞陷 (NETs) 与癌症进展有关,但它们在OS中的作用尚不清楚.
研究的目的:
- 在OS中调查免疫细胞透和NETs形成.
- 确定NET与化疗反应和患者存活率的关联.
主要方法:
- 追溯的队列研究.
- 帕拉芬嵌入的组织样本的免疫光.
- 在OS和骨质母细胞瘤样本中分析免疫细胞和NET.
主要成果:
- 骨质组织样本显示了比骨质母细胞瘤更高的NETs形成.
- 在诊断活检中,高的NET负担预测了化学疗法反应不佳和整体存活率降低.
- 与初级瘤相比,转移部位增加了NET;OS血清在健康的中性粒细胞中诱导了NET.
结论:
- 网在OS瘤微环境中起着重要作用.
- NETs可以作为OS治疗反应和生存的独立预后因素.
- 这些发现可能有助于开发针对骨髓瘤的向治疗方法.
更多相关视频
07:36Author Spotlight: Neutrophil Extracellular Traps Imaging in Human and Mouse Tissues
Published on: August 18, 2023
5.7K
11:32Real-Time, High-Throughput Microscopic Quantification of Human Neutrophil Extracellular Trap Release and Assessing the Pharmacology of Antagonists
Published on: October 18, 2024
511
相关概念视频
Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
