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在中风后认知障碍中,小脑活动异常和小脑 - 边缘系统的连接性改变:基于静止状态功能磁共振成像的研究

Haiyi Zhang¹, Juan Lu¹, Lu Zhang²

¹Department of Magnetic Resonance Imaging, The Affiliated Traditional Chinese Medicine Hospital, Luzhou, Sichuan, China.

Frontiers in neuroscience

|April 3, 2025

概括

脑卒中后认知障碍 (PSCI) 影响小脑神经元活动和与边缘系统的功能连接. 这些大脑变化与中风幸存者的认知衰退严重程度相关.

科学领域:

神经科学是一个神经科学.
认知科学认知科学
放射学放射学是一门学科.

背景情况:

脑卒中是导致认知障碍的主要原因.
脑卒中后认知障碍 (PSCI) 是中风后的一个常见疾病.
在PSCI中小脑的参与在很大程度上是未被探索的.

研究的目的:

研究PSCI对小脑神经元活动和边缘连接性的影响.
探索认知障碍严重程度与大脑变化之间的关系.

主要方法:

包括31名PSCI患者和31名对照.
使用迷你心理状态检查 (MMSE) 和蒙特利尔认知评估 (MoCA) 评估认知.
通过使用低频波动幅度 (ALFF),分数ALFF (fALFF) 和区域同质性 (ReHo) 以及边缘连接性来分析大脑活动.

主要成果:

在大脑_7b_R和大脑_Crus1_L中增加了ALFF.
在Vermis_3.3.中增加了fALFF.
在大脑_8_R,大脑_Crus2_R和大脑_Crus1_L.L.中增加了ReHo.
在前面_中_圆_L和大脑_Crus2_R.之间功能连接性下降.
降低海马_L和大脑_Crus2_R.之间的功能连接.
在Vermis_3和Frontal_Med_Orb_L.L.之间功能连接性下降.

结论:

小脑神经元活动的改变与PSCI的认知衰退有关.
认知障碍的严重程度可能与中断的小脑 - 边缘功能连接相关.

关键词:

小脑小脑是什么意思功能性磁共振成像技术功能性磁共振成像技术边缘系统的边缘系统.轻度的认知障碍轻度的认知障碍一次性中风中风中风中风中风

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