在持久的姿势感知性头患者中,药物治疗的长期结果
Chihiro Yagi1, Akira Kimura1, Ryota Kai1
1Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Frontiers in neurology
|April 3, 2025
概括
长期使用血清抗抑郁药物有效治疗持久性姿势感知头 (PPPD),改善症状长达三年. 然而,这种治疗并不能解决PPPD患者潜在的体感官过敏症.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 持久性姿势感知头 (PPPD) 是一种慢性神经瘤学障碍,影响空间定向.
- 目前的理解表明,PPPD涉及感官重权,使用血清抗抑郁药作为主要治疗方法.
- 在PPPD患者中缺乏抗抑郁药的长期疗效数据.
研究的目的:
- 评估在被诊断患有PPPD的患者中使用血清激素抗抑郁药的长期疗效和安全性.
- 评估抗抑郁药治疗开始后长达三年的治疗结果.
主要方法:
- 一组43名PPPD患者接受了抗抑郁药,结果使用头障碍清单 (DHI),医院焦虑和抑郁量表 (HADS) 和尼加塔PPPD问卷 (NPQ) 进行评估.
- 在多个时间点进行测量,长达3年,与头倾斜感知增益 (HTPG) 一起进行测量,以评估体感官过敏性.
- 治疗响应者被定义为1年后DHI得分改善≥18点.
主要成果:
- DHI,HADS和NPQ分数的显著改善持续了3个月至3年.
- 在43名患者中,有27名患者 (62.8%) 在1年后被归类为治疗响应者.
- 虽然通常是安全的,但在26名患者中报告了恶心等初始不良事件,但是暂时的. 头部倾斜感知增益没有显著改善.
结论:
- 血清抗抑郁药在治疗PPPD症状方面表现出长期的有效性和安全性.
- 药物治疗没有显著改善体感过敏,这是PPPD的潜在临床特征.
- 未来的研究应该集中在针对过敏症的治疗方法上,以潜在地提高PPPD治疗结果.
相关概念视频
Equilibrium and Balance
4.3K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
4.3K
Psychosis: Goals of Pharmacotherapy
98
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
98
The Vestibular System
39.0K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
39.0K
Parkinson's Disease: Treatment
162
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
162
Drug Therapy
32
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
32


