根据CABG中左心室功能的基线特征和1年结果 偏好 CABG中左心室功能
Ulrika Löfström1,2, Cecilia Linde2,3, Maria J Eriksson4,5
1Department of Cardiology, Capio St. Görans Hospital, Sankt Göransplan 1, SE-112 81 Stockholm, Sweden.
European heart journal open
|April 3, 2025
概括
选择性冠状动脉旁路移植 (CABG) 患者经常出现左心室 (LV) 功能障碍. 意想不到的是,那些在基线正常的LV功能的人在CABG后一年表现出心脏和功能恶化.
科学领域:
- 心脏病学 心脏病学
- 心脏外科手术 心脏外科手术
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 左心室 (LV) 功能障碍是接受冠状动脉旁路移植 (CABG) 患者的关键因素.
- 基于LV功能的表型患者 (保留喷射分数[pEF],减少喷射分数[rEF]和正常) 对于理解结果至关重要.
- 在CABG PREFERS队列研究中,前性地检查了这些表型.
研究的目的:
- 根据基线和1年LV功能,对接受选择性CABG的患者进行表征.
- 为了研究心脏功能,生物标志物和功能在CABG后的不同LV功能表型中的变化.
主要方法:
- 前性,单中心队列研究 (CABG PREFERS).
- 使用心声学和NT-proBNP对136名选择性CABG患者进行分类,分为pEF,rEF和正常的LV功能组.
- 基线和1年后的评估包括心电图,心声图,心脏MRI,实验室测试和生活质量.
主要成果:
- 45%的患者表现出LV功能障碍 (25%的pEF,20%的rEF).
- 一年后,LV功能正常的患者在E/é (7.8-8.9),NT-proBNP (150-182 ng/L) 和eGFR (82.5-78.9 mL/min/1.73 m2) 中显著恶化.
- 在pEF和rEF组中观察到心声学参数的改善.
结论:
- 在选择性CABG患者中,LV功能障碍很普遍.
- 患者最初的LV功能正常,手术后一年内发生了缩/透缩功能,NT-proBNP和eGFR的不良变化.
- 需要进一步的研究来了解这些发现对长期结果的影响.
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