突触介导不同类型的压力对工作记忆的影响:一个由大脑启发的神经网络研究
Chengcheng Du1,2,3, Yinqian Sun1,2,3, Jihang Wang1,2,3
1Brain-inspired Cognitive Intelligence Lab, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Frontiers in cellular neuroscience
|April 3, 2025
概括
急性压力通过促进突触电流来增强工作记忆,而慢性压力通过减少神经元连接和GABAergic调节来损害工作记忆. 这会影响认知功能和神经网络模型.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 认知科学 认知科学
背景情况:
- 无论是急性还是慢性压力,都会显著影响认知功能,特别是工作记忆.
- 了解压力对工作记忆的影响背后的神经机制对于解决认知障碍至关重要.
研究的目的:
- 调查急性和慢性压力对前额叶皮层神经网络模型中的突触调制的差异影响.
- 探索这些压力条件如何影响突触和神经元水平上工作记忆的表现.
主要方法:
- 利用一种生物灵感,数据驱动的动物前额神经网络模型,包括具有AMPA,NMDA和GABA突触的刺激和抑制神经元.
- 模拟工作记忆任务使用短期回忆范式来评估神经元群体的信息保留能力.
主要成果:
- 发现急性压力通过增加AMPA和NMDA突触电流来增强工作记忆信息保留.
- 慢性压力导致树突脊柱密度降低,GABA电流的调节作用降低,对工作记忆产生负面影响.
- 慢性压力造成的结构损伤因具有相似选择性的刺激神经元之间强烈的连接而加剧.
结论:
- 急性和慢性压力对突触可塑性和与工作记忆相关的神经网络动态产生明显的调节效应.
- 研究结果提供了对不同压力范式下的工作记忆缺陷神经基础的见解.
- 这项研究强调了突触功能和神经元连接在调解压力诱导的认知变化的重要性.
更多相关视频
相关概念视频
The Sympathetic Nervous System
93.9K
Overview
93.9K
Role of Neurotransmitters in Memory
334
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
334
Working Memory
97
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
97
Overview of Synapses
2.1K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the...
2.1K
Storage
57
A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
57
Physiological Foundation of Stress
28
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
28


