在活跃但不是假的间歇性达爆发刺激后,皮质脊髓刺激度调节的高度依赖变化
Abdulhameed Tomeh1, Abdul Hanif Khan Yusof Khan1,2, Zalina Abu Zaid3,4
1Department of Neurology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
IBRO neuroscience reports
|April 3, 2025
概括
运动皮层的间歇性达爆发刺激 (iTBS) 显示了不同的结果. 受试者的身高与刺激反应有意想不到的相关性,这表明它会影响神经可塑性,并且在未来的运动皮层iTBS研究中需要进一步调查.
科学领域:
- 神经科学是一个神经科学.
- 神经生理学 神经生理学
- 发动机控制器的控制器
背景情况:
- 人类运动皮层 (M1) 的间歇性甲爆刺激 (iTBS) 显示出不良的可重复性和高的个体间变异性.
- 了解影响iTBS疗效的因素对于优化神经调节疗法至关重要.
研究的目的:
- 调查iTBS对M1.0的影响的可重现性.
- 探索潜在的影响因素,包括生理测量和人体测量,对iTBS反应.
- 为未来的M1-iTBS研究提供方法建议.
主要方法:
- 一个随机的,模拟控制的交叉研究,涉及17名健康成年人.
- 经磁刺激 (TMS) 引起的运动唤起潜力 (MEP) 在iTBS后的多个时间点上被测量.
- 二次测量包括血压,心率,毛细血管血糖,以及主观感觉问卷 (TMSens_Q).
主要成果:
- 对于MEP振幅,MEP延迟,血压,心率或血糖没有发现显著的时间×干预相互作用效应.
- 在活跃和假 iTBS 条件中,嗜睡是最常见的感觉 (82.3%).
- 在活跃的iTBS组中,受试者的身高与正常化的MEP幅度有显著的负相关性,特别是在较晚的时间点.
结论:
- 标准的生理测量和主观感觉无法解释iTBS反应的变化.
- 研究对象的身高成为影响iTBS诱导的M1神经可塑性的重要,意想不到的因素.
- 未来的研究应该调查身高对M1-iTBS疗效的影响,并将其考虑在研究方案中.
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