在患有直肠癌的患者中,国家实施Watch-and-Wait
Barbara M Geubels1,2,3, Brechtje A Grotenhuis1, Aart-Jan van den Esschert1
1Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.
The British journal of surgery
|April 3, 2025
概括
在荷兰广泛实施观察和等待 (W&W) 对于直肠癌,结果与专家中心相似. 这种方法实现了高的器官保存率和存活率,证明了其在大量医院的可行性.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 对直肠癌的观察和等待 (W&W) 结果通常来自专门的中心.
- 本研究评估了在荷兰广泛,全国范围内实施W&W的结果.
研究的目的:
- 评估多个大量医院的Watch-and-Wait (W&W) 实施的可行性和结果.
- 随着时间的推移,比较不同实施阶段的结果.
主要方法:
- 在2004年至2022年期间,对1080名接受W&W治疗的直肠癌患者进行了基于注册表的分析.
- 患者在 (化疗) 放射治疗后获得临床反应,并分为三个时间队列进行分析.
- 评估的结果包括局部再生,远程转移,生存和器官保存.
主要成果:
- 观察到3年的局部再生发病率为23%,器官保存率为76%.
- 三年远程转移率为10%,总生存率为97%.
- 在三个队列之间没有发现局部再生或远程转移的显著差异,这表明在实施期间的结果一致.
结论:
- 在荷兰大规模医院广泛实施观察和等待 (W&W),结果与专家中心的结果相当.
- 在真实世界中,W&W方法在直肠癌管理的多机构环境中显示出强大的有效性和安全性.
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