Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

682
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
682

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Coupled heat and moisture transfer in elliptical semi-permeable membrane fiber bundles for membrane distillation desalination.

Water research·2025
Same author

Optimized intraorbital optic nerve exposure: a translational surgical paradigm for neural regeneration in rat model.

International ophthalmology·2025
Same author

Role of Bubble Evolution in the Bubble-Propelled Janus Micromotors.

Micromachines·2023
Same author

Correction: Targeted Next-Generation Sequencing for Clinical Diagnosis of 561 Mendelian Diseases.

PloS one·2016
Same author

DDQ-Mediated Oxidative Radical Cycloisomerization of 1,5-Diynols: Regioselective Synthesis of Benzo[b]fluorenones under Metal-Free Conditions.

Organic letters·2016
Same author

Correction: Feasibility of Elective Nodal Irradiation (ENI) and Involved Field Irradiation (IFI) in Radiotherapy for the Elderly Patients (Aged ≥ 70 Years) with Esophageal Squamous Cell Cancer: A Retrospective Analysis from a Single Institute.

PloS one·2016

相关实验视频

Updated: May 17, 2025

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
06:10

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

1.5K

甲素B促进视神经的轴突再生.

Si Zhang1, Hui Zhu2, Guopei Li1

  • 1Department of Ophthalmology, The First People's Hospital of Foshan.

Neuroreport
|April 3, 2025
PubMed
概括

卡瑟普辛B (CTSB) 在视神经损伤的微环境中降解胆素硫酸蛋白甘 (CSPGs). 这种作用促进了轴突的再生,这表明CTSB是光神经再生的治疗点.

科学领域:

  • 神经科学是一个神经科学.
  • 再生医学是一种再生医学.
  • 分子生物学分子生物学

背景情况:

  • 视神经受伤通常会导致由于痕组织中的抑制分子而导致有限的再生.
  • 丁硫酸盐蛋白质甘氨酸 (CSPGs) 是阻碍轴突生长的质痕的关键抑制成分.
  • 了解克服痕抑制的分子机制对于开发有效的再生疗法至关重要.

研究的目的:

  • 为了研究 cathepsin B (CTSB) 在视神经再生的作用.
  • 为了确定CTSB是否可以在视神经受伤后修改抑制性微环境.
  • 通过质细胞中的信号通路探索CTSB的调节.

主要方法:

  • 在Sprague-Dawley大鼠的视神经压碎和远程压碎损伤模型中.
  • 基因和蛋白质表达分析使用RT-qPCR和西方布洛特.
  • 在体外研究中使用初级皮质神经元和BV2微质细胞.
  • 定量蛋白质组学用于识别再生微环境中的变化.

主要成果:

  • 当地给药CTSB降解了CSPG,并在体内促进了轴突再生.
  • 在体外中,CTSB中和了CSPG介导的神经元外生抑制.

更多相关视频

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
11:02

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Published on: May 12, 2011

13.4K
Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
07:57

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

3.8K

相关实验视频

Last Updated: May 17, 2025

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
06:10

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

1.5K
Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
11:02

Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Published on: May 12, 2011

13.4K
Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
07:57

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

3.8K
  • 定量蛋白质组学揭示了再生环境中的微质标记物增加.
  • 微质中STAT3和STAT6通路的激活导致CTSB分泌量增加.

    • 结论:

    • 在受伤后的微环境中,高调的CTSB会降解CSPG,促进视神经的轴突生长.
    • 通过STAT3 / STAT6信号调节的微质衍生的CTSB在视神经再生中发挥着重要作用.
    • 调节CTSB活动是通过改变受伤微环境来增强视神经修复的潜在治疗策略.