受回归性自闭症和非回归性自闭症影响的个体之间的表型和基因型差异的比较分析:一个横截面研究
Seyed Hassan Tonekaboni1, Alana Iaboni1, Brett Trost2
1Autism Research Centre, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
概括
经历发育回归的自闭症青少年表现出较低的认知和适应功能. 与没有回归的人相比,这个子组的发病率也更高.
科学领域:
- 神经发育障碍 神经发育障碍
- 自闭症谱系障碍研究研究
- 儿科心理学 儿科心理学
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出多样化的发展轨迹.
- 自闭症儿童的一个子集经历了发育回归,其特点是技能丧失.
- 识别与回归相关的因素对于理解ASD异质性至关重要.
研究的目的:
- 为了比较自闭症青少年的发展概况,有和没有回归.
- 识别与回归自闭症相关的因素.
- 调查导致自闭症发育回归的遗传和环境因素.
主要方法:
- 分析了来自安大略省神经发育障碍 (POND) 网络的930名参与者的数据.
- 使用自闭症诊断面试修订 (ADI-R) 进行回归的分类.
- 在回归和非回归组之间比较人口,医学,心理健康,认知,适应和遗传数据.
主要成果:
- 22.7%的参与者表现出回归自闭症.
- 回归组的全尺度智商和适应性功能 (ABAS-2) 评分明显较低.
- 在回归组中观察到的更高患病率 (p=0.001);精神健康 (CBCL) 或核心症状严重程度 (SCQ) 没有显著差异.
结论:
- 患有回归的自闭症青少年表现出较差的认知和适应性结果.
- 在自闭症患者中更为普遍,有回归.
- 需要进一步的研究来阐明自闭症回归的基因组基础.
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