运动训练恢复了与长寿相关的托芬代谢物3 - 基甲酸水平在中年成人中
Niklas Joisten1,2, Marcel Reuter3,4, Friederike Rosenberger4
1Division of Exercise and Movement Science, Institute for Sport Science, University of Göttingen, Göttingen, Germany.
Acta physiologica (Oxford, England)
|April 3, 2025
概括
运动训练可以增强3-基谷氨酸 (3-HAA),这是与长寿相关的代谢物. 这项研究证实了3-HAA与人类衰老的关联,并证明了运动.
科学领域:
- 代谢学与衰老的关系
- 运动生理学 运动生理学
- 基努瑞宁路径 基努瑞宁路径
背景情况:
- 临床前研究表明,托芬代谢物3 - 酸 (3-HAA) 和寿命延长之间存在联系.
- kynurenine 途径 (KP) 在这种关联中发挥作用,其中特定的酶如 KYNU 和 HAAO 是关键的.
- 将这些发现转化为人类,并探索像运动这样的非药物干预措施至关重要.
研究的目的:
- 在人类中研究与3-HAA相关的核心KP酶 (KYNU,HAAO) 的进化保存.
- 为了检查血清3-HAA,它的前体人酸和成年人的年龄之间的关联.
- 确定不同耐力运动训练模式对3-HAA水平和相关的KP代谢物的影响.
主要方法:
- 分析了KYNU和HAAO的进化保护.
- 针对年轻至中年成年人的横截面研究 (N=84),以评估血清3-HAA和人类酸与年龄的相关性.
- 26周的耐力运动干预比较增强强度 (INC,n=17) 与适度持续训练 (CON,n=17) 匹配的能量消耗.
主要成果:
- 与3-HAA相关的核心KP酶在人类的进化过程中得到了保留.
- 在成人队列中,血清3-HAA和人类酸水平与年龄有显著的关联.
- 与基线相比,INC和CON运动显著增加了3-HAA水平 (分别为134%和85%).
结论:
- 在动物模型中观察到的全身3-HAA水平与衰老之间的关联被转化为人类.
- 长期的运动训练是一种有效的策略,可以提高中年成人体内的全身3HAA水平.
- 研究结果表明,3-HAA可能会调解训练适应,健康益处和寿命.
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