癌症患者感染死亡 癌症患者感染死亡
Mckenzee Chiam1,2,3, Kyle Mani4,2, Xi Wang5
1Department of Radiation Oncology, Penn State Cancer Institute.
American journal of clinical oncology
|April 3, 2025
概括
患有癌症的患者面临着明显更高的感染死亡风险,特别是在诊断后的第一年. 老年人,男性,黑人和未婚人士是最脆弱的,需要有针对性的感染预防策略.
科学领域:
- 在瘤学瘤学.
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 感染死亡率是癌症患者的关键问题.
- 早期识别高风险个体对于有效的预防策略至关重要.
研究的目的:
- 在美国一大批癌症幸存者的感染特异性死亡风险的特征.
- 确定与癌症患者致命感染相关的人口和时间因素.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库的7,529,481名美国癌症幸存者 (1992-2015) 的数据.
- 计算了标准化死亡率 (SMR),并进行了细灰色生存率分析,以调整竞争风险.
主要成果:
- 1.3%的癌症幸存者 (101,167) 因感染而死亡,与普通人口相比,SMR为3.29.
- 在老年,男性,黑人和未婚患者中观察到更高的风险.
- 感染死亡风险在诊断后的第一年是最高的 (SMR:8.68) 并随着时间的推移而降低,尽管它仍然很高 (>10年:SMR:2.93).
- 某些癌症,如霍奇金淋巴瘤,非霍奇金淋巴瘤和卡波西肉瘤,由于感染而导致的早期死亡比例很高,而肝癌随着时间的推移显示出相对感染死亡风险的增加.
结论:
- 这项研究提供了癌症患者感染死亡率模式的详细描述.
- 结果可以为开发有针对性的研究和干预措施提供信息,以减少这一脆弱人群中感染相关的死亡.
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