经过乳腺癌诊断后的历史红线和全因生存率
Sarah M Lima1, Tia M Palermo1, Furrina F Lee2
1University at Buffalo, Buffalo, NY, United States.
概括
历史上的红线,一个歧视性的住房政策,与较低的乳腺癌存活率有关. 较差的红线等级与死亡率的增加相关,突出显示了持久的健康差异.
科学领域:
- 环境流行病学环境流行病学
- 健康差距 研究 研究 研究 研究
- 在瘤学瘤学.
背景情况:
- 历史上的红线政策创造了种族隔离的社区.
- 通过红线划分分类的街区仍然存在不同的配置文件.
- 过去的红线可能有助于目前的乳腺癌存活率差异.
研究的目的:
- 评估纽约州乳腺癌患者的历史红线级和5年生存率之间的关联.
- 测试该假设,较差的红线分级与生存率降低有关.
主要方法:
- 利用纽约州癌症登记处的60,773例乳腺癌病例 (2008-2018) 的队列.
- 在诊断时将历史红线分级 (A-D) 分配给患者人口普查片.
- 采用考克斯模型来估计5年死亡率的危险比率 (HRs),按患者和邻里因素分层.
主要成果:
- 在红线等级 (P < 0.001) 中观察到显著的生存梯度.
- 与A等级相比,B,C和D等级的死亡率分别增加了29%,37%和64% (P<0.001).
- 经过对保险和治疗进行调整后,这些关联仍然存在,种族/种族和社区特征的显著相互作用.
结论:
- 历史红线级逐渐与较低的乳腺癌存活率有关.
- 观察到的差异并不能完全通过获得医疗保健或当前邻里条件来解释.
- 这项研究表明,历史上的红线对当代乳腺癌结果的持久影响.
更多相关视频
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
187
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
8.8K
相关概念视频
Cancer Survival Analysis
311
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
311
Comparing the Survival Analysis of Two or More Groups
96
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
96
Kaplan-Meier Approach
62
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
62
Truncation in Survival Analysis
135
Truncation in survival analysis refers to the exclusion of individuals or events from the dataset based on specific criteria related to the time of the event. This exclusion can happen in two primary forms: left truncation and right truncation.
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
Left truncation occurs when individuals who experienced the event of interest before a certain time are not included in the study. This is often due to a "delayed entry" into the study where only those who survive until a certain entry point are...
135
Introduction To Survival Analysis
134
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
134
Censoring Survival Data
50
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
50
