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Updated: May 10, 2026

Avidity-based Extracellular Interaction Screening AVEXIS for the Scalable Detection of Low-affinity Extracellular Receptor-Ligand Interactions
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综合红色试验,一种标准化的体外试验方案,用于量化自毒素抑制剂的疗效

Elli-Anna Stylianaki1, Christiana Magkrioti1, Eleanna Kaffe1

  • 1Insitute for Fundamental Biomedical Research, Biomedical Sciences Research Center "Alexander Fleming," Athens, Attica 16672, Greece.

STAR protocols
|April 3, 2025
PubMed
概括

这项研究引入了一种新的检测方法,用于发现和研究自毒素 (ATX) 抑制剂. 这种方法有助于开发新的治疗方法,治疗诸如肺纤维化和胰腺癌等疾病.

关键词:
癌症 癌症 癌症 癌症化学 化学 化学健康科学 卫生科学 卫生科学蛋白质生物化学 蛋白质生物化学

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...