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相关概念视频

Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...

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Multi-objective optimization in population pharmacokinetic model selection and optimization: application of NSGA-II in pyDarwin.

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相关实验视频

Updated: May 12, 2026

Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology
08:54

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Published on: April 18, 2018

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使用Simcyp R包进行PBPK模拟工作流程与Simcyp模拟器.

Anthonia M Onasanwo1, Naresh Mittapelly1, Laura Shireman1

  • 1Certara Predictive Technologies, Sheffield, UK.

CPT: pharmacometrics & systems pharmacology
|April 3, 2025
PubMed
概括
此摘要是机器生成的。

本研究引入了一个R包,用Simcyp模拟器自动化生理学基础的药理动力学/药理动力学 (PBPK/PD) 建模. 这种整合简化了复杂的药物开发模拟,将分析时间从几天缩短到几个小时.

关键词:
在 PBPK 建模中使用 PBPK 模型.R 统计软件 统计软件模拟工作流程的工作流程.

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科学领域:

  • 药理动力学和药理动力学
  • 计算生物学 计算生物学
  • 药物开发 药物开发

背景情况:

  • 基于生理学的药理动力学/药理动力学 (PBPK/PD) 建模对于理解体内药物行为至关重要.
  • 模拟器Simcyp是一个强大的商业工具,用于PBPK/PD模拟.
  • 将R与PBPK/PD软件集成可以提高效率和分析能力.

研究的目的:

  • 描述一个与Simcyp模拟器接口的R包 (23.0.64版本).
  • 展示PBPK/PD模型开发和验证的自动化工作流程.
  • 展示加速模拟执行,分析和可视化.

主要方法:

  • 开发一个R包来控制Simcyp模拟器输入和过程输出.
  • 实施用于模型验证和虚拟生物等价性评估的自动化工作流程.
  • 利用R进行脚本编写,自动化,统计分析和结果可视化.

主要成果:

  • 成功地将R与Simcyp模拟器集成,用于自动PBPK/PD建模.
  • 证明了阿塔萨纳维尔药物相互作用模型的验证.
  • 展示了对帕利皮里顿棕酸盐长效注射悬浮剂的虚拟生物等价性评估.
  • 显著减少模拟和分析时间,从几天减少到几个小时.

结论:

  • 该R包显著提高了使用Simcyp模拟器的PBPK/PD建模的效率.
  • 自动化工作流程有助于更快,更强大的药物开发和临床研究.
  • 这种方法加快了对药物相互作用和生物等价性的评估.