家庭运动计划对化疗诱导的外周神经病变和生活质量的影响:单盲随机对照试验
Necmiye Çömlekçi1, Gülbeyaz Can, Faruk Taş
1Author Affiliations: Department of Nursing, Faculty of Health Sciences, Bartın University, Bartın (Dr Çömlekçi); and Florence Nightingale Faculty of Nursing, İstanbul University-Cerrahpaşa (Dr Can); and Department of Medical Oncology, Institute of Oncology, İstanbul University (Dr Taş), İstanbul, Türkiye.
Cancer nursing
|April 3, 2025
概括
在家进行的运动计划显著降低了化疗诱导的周围神经病变 (CIPN) 症状,并改善了接受癌症治疗的患者的生活质量. 这种干预为管理CIPN提供了一个有前途的方法.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 康复医学 康复医学 康复医学
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是癌症治疗的常见和衰弱的副作用,严重影响患者的生活质量.
- 虽然运动被认为是对外围神经病变有益的干预措施,但支持其有效性的强有力的证据,特别是对CIPN,仍然有限.
研究的目的:
- 评估家庭炼计划在缓解CIPN严重程度和症状方面的有效性.
- 确定这种运动干预对患者整体生活质量的影响.
主要方法:
- 2020年9月至2022年8月期间进行的一项随机对照试验,涉及72名参与者 (37名干预者,35名对照者).
- 干预组在8周内每天两次执行家庭运动计划;对照组接受标准护理.
- 使用常用术语对不良事件的标准来评估外围神经病变,而通过EORTC QLQ-CIPN20和EORTC QLQ-C30问卷来衡量生活质量和症状.
主要成果:
- 与对照组相比,运动组的参与者在干预后8周表现出明显较低的外围神经病症症状得分 (P < .001).
- 对于感官 (d = 3.47) 和运动 (d = 2.76) 神经病症得分,观察到很大的效应大小.
- 干预组在干预后报告了显著更高的生活质量得分 (P < .001),效果大小很大 (η2 = 0.45).
结论:
- 在家进行的运动计划有效地减少了化疗引起的外周神经病变的严重程度和症状.
- 这种运动方案,包括感觉,强化和平衡组件,可以整合到护理实践中,以增强患者护理和改善CIPN的结果.
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