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相关概念视频

Neurulation01:30

Neurulation

41.5K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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The Cochlea01:13

The Cochlea

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The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
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Auditory Pathway01:15

Auditory Pathway

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Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
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Hair Cells01:22

Hair Cells

39.9K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
39.9K
Anatomy of the Ear01:16

Anatomy of the Ear

7.1K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
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相关实验视频

Updated: May 21, 2025

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
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Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

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外皮条形码显示神经和耳区分

Sandra de Haan1,2,3, Jingyan He1, Agustin A Corbat1

  • 1Department of Cell and Molecular Biology, Karolinska Institutet, Solna, Sweden.

Science (New York, N.Y.)
|April 3, 2025
PubMed
概括
此摘要是机器生成的。

这项研究使用老鼠先进的谱系追踪来追踪脊椎动物的发育. 研究人员从神经和斑块中发现了不同的细胞系,

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Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation
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Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation

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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
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相关实验视频

Last Updated: May 21, 2025

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation
09:03

Culture of Embryonic Mouse Cochlear Explants and Gene Transfer by Electroporation

Published on: January 12, 2015

12.8K
Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation
06:45

Gene Transfer into the Chicken Auditory Organ by In Ovo Micro-electroporation

Published on: April 17, 2016

9.4K
Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research
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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

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科学领域:

  • 发育生物学
  • 神经科学
  • 遗传学

背景情况:

  • 脊椎动物的发育依赖于斑点和神经细胞.
  • 了解它们的精确血统和分化对于发育生物学和神经科学至关重要.

研究的目的:

  • 为了研究小鼠神经的血统.
  • 阐明融合差异化途径并识别不同的细胞系.
  • 提供早期神经系统和内耳发育的基础见解.

主要方法:

  • 在小鼠的胚胎7. 5天内进行纳米注射.
  • 可以遗传的DNA条形码来追踪血统.
  • 高通量,下一代单细胞血统的追踪.
  • 进行克隆分析.

主要成果:

  • 成功准外皮,包括神经和斑点,以进行有效的操纵.
  • 阐明了融合差异化路径.
  • 识别出不同的神经系统,神经和眼衍生的血统.
  • 发现早期的神经和耳区分.

结论:

  • 这项研究提供了脊椎动物早期细胞系的高分辨率地图.
  • 确定了不同细胞类型的原始细胞关系.
  • 提供神经科学和发育生物学研究的基础见解.