中年和老年人大麻使用和主观认知衰退:对行为风险因素监测系统调查的分析
Xiao Chen1, Peilu Wang1, Yilin Tang2
1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Zhongshan Hospital, Fudan University, Shanghai, China.
Journal of Alzheimer's disease : JAD
|April 3, 2025
概括
成年人使用大麻与主观认知衰退 (SCD) 的增加有关. 频繁使用者表现出更高的认知问题的几率,这表明剂量-反应关系. 需要进一步的研究来证实这些发现.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 大麻对青少年大脑发育的影响已知,但其与成年人认知能力下降的关联仍未得到充分研究.
- 主观认知衰退 (SCD) 在老年人中越来越令人担忧,影响日常功能.
研究的目的:
- 为了研究大麻使用与过去一年的主观认知衰退 (SCD) 在美国45岁及以上的成年人之间的横截面关联.
- 在这个人口群体中探索大麻使用频率和SCD之间的关系.
主要方法:
- 利用了来自100,685名参与者在行为风险因素监测系统 (BRFSS) 的五个周期中的数据.
- 参与者分为非使用者,偶尔使用者 (<10天/月) 和经常使用者 (≥10天/月) 的大麻.
- 采用加权,多变量逻辑回归,根据年龄,性别,教育和慢性疾病状况等混因素进行调整.
主要成果:
- 过去一个月的大麻使用与去年SCD的更高几率显著相关 (OR = 1.70).
- 观察到一种剂量与反应的关系,经常使用大麻与SCD的更大概率有关 (p趋势<0.001).
- 对于与SCD相关的功能限制也发现了类似的关联.
结论:
- 过去一个月的大麻使用者报告了更高的主观认知衰退率.
- 这些发现与现有的文献相一致,表明大麻使用可能与成年人的认知能力下降有关.
- 建议进行前性研究,以验证这些关联并探索因果关系.
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