在对外围T细胞淋巴瘤进行自身干细胞移植后,用罗米德素进行维持疗法
Niloufer Khan1, Parastoo B Dahi2, Farhad Khimani3
1City of Hope, Duarte, California, United States.
Blood advances
|April 3, 2025
概括
自体干细胞移植后维护罗米德素在外周T细胞淋巴瘤患者中显示了62%的2年无进展生存率,这表明尽管未达到主要终点,但可行性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 周围T细胞淋巴瘤 (PTCL) 的结果不好.
- 自主造血干细胞移植 (AHCT) 为缓解期的PTCL患者提供了改善的无进展生存率 (PFS).
- 罗米德普辛是一种被批准用于复发性/耐药性PTCL的基因组脱乙酶抑制剂.
研究的目的:
- 评估在AHCT后接受罗米德素维持治疗的PTCL患者的2年无进展生存期 (PFS).
- 评估romidepsin维持治疗在这个患者群体中的可行性和安全性.
主要方法:
- 一项多中心研究涉及47名接受AHCT与BEAM调节的患者.
- 在AHCT后,罗米德素维持疗法以特定的剂量和时间表进行.
- 使用Kaplan-Meier分析估计了无进展生存期.
主要成果:
- 该研究评估了26名患者在队列1为2年PFS的初级终点.
- 在可评估患者中,估计的2年PFS为62% (95% CI:45-83%).
- 常见的毒性包括疲劳,血小板减少和贫血,5名患者需要降低剂量.
结论:
- 在PTCL患者中,AHCT后的维护性罗米德素治疗是可行的.
- 估计2年的PFS为62%,与历史数据相比,这表明潜在的好处,尽管主要终点未达到.
- 在AHCT后的PTCL中,对于romidepsin维持的进一步调查可能是有必要的.
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