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肠道微生物群的特征和预后价值在患有动脉瘤下arachnoid出血的患者:一项临床研究
Pengzhao Zhang1, Yang Liu2, Mengyuan Xu2
1Graduate School of Xinxiang Medical University, Xinxiang, PR China.
概括
动脉瘤下arachnoid出血 (aSAH) 与肠道微生物群组成和多样性的显著变化有关. 这些微生物变化显示出潜在的生物标志物用于诊断aSAH和预测患者预后.
科学领域:
- 微生物组研究的研究.
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 神经瘤下关节出血 (aSAH) 是一种关键的神经疾病.
- 肠道微生物群在aSAH病原和预后中的作用尚未完全理解.
研究的目的:
- 描述aSAH患者与对照者的肠道微生物群差异.
- 调查与aSAH预后相关的微生物变化.
- 探索肠道微生物群对aSAH结果的预测价值.
主要方法:
- 来自aSAH患者和健康对照的便样本的元基因组测序.
- 对肠道微生物群组成,多样性和丰富性的比较分析.
- 微生物群,临床标志物和aSAH严重程度之间的相关性分析.
- 在aSAH后三个月的预后评估.
主要成果:
- 在aSAH患者和对照人群之间观察到肠道微生物群组成,多样性和丰度的显著差异.
- 在预后好和预后差的组之间确定了不同的微生物概况.
- 五个属 (Bacillus,Eggerthia,Hominisplanchenecus,Carnobacterium,Bifidobacterium) 已经成为潜在的预测生物标志物.
结论:
- 与健康个体相比,患有aSAH的患者表现出改变的肠道微生物群.
- 这些肠道微生物变化代表了aSAH诊断的潜在生物标志物.
- 肠道微生物群概况可以帮助预测aSAH的预后.
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