在感染性内心炎的成年患者中进行了当代队列研究
Mariana Giorgi Barroso de Carvalho1, Thatyane Veloso de Paula Amaral de Almeida1, Nicolas de Albuquerque Pereira Feijóo1
1Universidade do Grande Rio/Afya (UNIGRANRIO/Afya), Departamento de Medicina, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brazil.
这项研究详细介绍了巴西502例传染性内心炎 (IE) 病例,尽管经常进行手术,但死亡率很高. 血液培养负的左侧IE是常见的,强调了对这种严重的心脏感染需要有效的治疗策略.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 传染性内心炎 (IE) 在全球范围内具有显著的发病率和死亡率.
- 关于中等收入国家的IE病例系列的数据有限.
- 这项研究解决了巴西地区IE数据的需求.
研究的目的:
- 描述一系列大型的感染性内心炎患者在巴西参考中心接受治疗的病例.
- 将流行病学和临床数据与国际IE队列进行比较.
- 分析结果并确定影响IE患者死亡率的因素.
主要方法:
- 对前性维护的IE数据库 (2006-2023) 的回顾性分析.
- 包括确诊感染性内心炎的成年患者.
- 使用Jamovi®的文献综述和统计分析.
主要成果:
- 分析了502个IE发作;平均年龄为48.4岁;64.7%社区获得.
- 患病倾向包括类风湿性门疾病 (30.7%),假肢 (31.5%) 和先天性心脏病 (13.9%).
- 心力衰竭 (58%),功能衰竭 (32.8%) 和住院死亡率 (25%) 的高率;手术患者的死亡率较低 (21.3%).
结论:
- 血液培养负的左侧IE占主导地位.
- 观察到的高死亡率与国际IE系列一致.
- 频繁的手术干预与降低死亡率有关,这强调了它在IE管理中的重要性.
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