药物使用与多发性硬化症患者的认知缺陷有关
C Atiyeh1, A Garjani2, C Gilmartin2
1School of Medicine, University of Nottingham, Nottingham, UK.
Multiple sclerosis and related disorders
|April 3, 2025
概括
抗胆固醇和镇静药,以及多药,对患有多发性硬化症 (pwMS) 的人的认知功能产生负面影响. 处方者应谨慎行事,并考虑使用抑郁症的处方策略.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 认知科学 认知科学
背景情况:
- 患有多发性硬化症 (pwMS) 的人经常服用具有抗胆固醇和镇静作用的药物.
- 这些药物可能会导致pwMS的认知能力下降.
- 这项研究调查了这些药物和多药物对认知缺陷的短期影响.
研究的目的:
- 评估药物负担 (抗胆固醇和镇静作用) 和多药与pwMS认知缺陷之间的关联.
- 评估认知功能的客观和主观测量.
主要方法:
- 对486个pwMS进行了回顾性横截面研究.
- 使用药物负担指数 (DBI) 和抗胆效应对认知 (AEC) 尺度评估药物负担.
- 评估了客观认知 (通过符号替换任务处理速度) 和主观认知 (感知缺陷问卷-5).
- 使用多变量回归分析,根据相关的共变量进行调整.
主要成果:
- 较高的药物负担 (DBI和AEC) 与客观认知缺陷 (SST) 有显著的关联.
- 药物负担也与主观认知能力下降 (PDQ-5) 有关.
- 多药性 (≥5种药物) 与SST表现较差和PDQ-5分数较高有关.
结论:
- 抗胆固醇药物,镇静药物和多药物与pwMS的认知功能有负面关联.
- 在pwMS中处方这些药物需要仔细考虑.
- 对pwMS的减压策略进行进一步研究是有必要的.
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