适应性免疫系统在多发性硬化症的开始和持续中的作用
Ali Maisam Afzali1, Thomas Korn2
1Institute for Experimental Neuroimmunology, Technical University of Munich School of Medicine and Health, Ismaninger Str. 22, Munich 81675, Germany; Department of Neurology, Technical University of Munich School of Medicine and Health, Ismaninger Str. 22, Munich 81675, Germany.
Seminars in immunology
|April 3, 2025
概括
多发性硬化症 (MS) 涉及免疫细胞攻击中枢神经系统 (CNS). 本综述概念化了针对复发性和渐进性MS的适应性免疫细胞的疗法.
科学领域:
- 神经免疫学 神经免疫学
- 中枢神经系统 (CNS) 炎症 中枢神经系统 (CNS) 炎症
- 适应性免疫在神经疾病中
背景情况:
- 多发性硬化症 (MS) 是一种炎症性,去髓化的中枢神经系统疾病.
- 适应性免疫细胞,特别是T和B细胞,在中枢神经系统外被激活并迁移到中枢神经系统内,导致复发性MS的自身免疫性炎症.
- 在多发性硬化症中,疾病的进展涉及分隔性炎症和中枢神经系统居民细胞的慢性激活,关于组织居民适应性免疫细胞的作用的辩论越来越多.
研究的目的:
- 讨论适应性免疫细胞如何在中枢神经系统中启动和维持自身免疫性炎症的概念.
- 概念化针对复发性和进展性MS的适应性免疫细胞的治疗干预措施.
主要方法:
- 关于适应性免疫细胞参与多发性硬化病原的当前概念和文献的审查.
- 专注于适应性免疫,不包括中枢神经系统内在细胞反应.
- 讨论单细胞分析,揭示T和B细胞异质性.
主要成果:
- 适应性免疫细胞,通过外部激活,驱动复发性MS的发病.
- 通过先进的分析,T和B细胞的异质性是显而易见的.
- 组织内适应性免疫细胞在进展性多发性硬化症中的作用正在研究中.
结论:
- 了解适应性免疫细胞的作用对于MS的发病过程至关重要.
- 准适应性免疫细胞为复发性和渐进性MS提供了潜在的治疗策略.
- 对于综合性多发性硬化症治疗,需要对组织内适应性免疫进行进一步的研究.
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