使用合动量法进行流体结构相互作用的数字双胞胎的部署:对大动脉动脉瘤的案例研究
Giacomo Creazzo1, Guido Nannini1, Simone Saitta2
1Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Computers in biology and medicine
|April 3, 2025
概括
数字人类双胞胎 (DHT) 可以预测上升大动脉动脉瘤修复的结果. 与传统的达克隆移植相比,在DHT中使用合规的假肢显示出中度的血液动力学益处.
科学领域:
- 生物医学工程 生物医学工程
- 计算流体动力学的流体动力学.
- 医疗成像医学成像
背景情况:
- 上升大动脉动脉瘤修复通常使用达克隆移植,其遵守性低于本土组织,可能导致不良的血液动力学变化.
- 数字人类双胞胎 (DHT) 提供了一个有希望的in-silico方法来预测患者特定的结果并优化治疗策略.
研究的目的:
- 为胸前前动脉开发一个数字人双胞胎 (DHT) 管道,以评估替代达克朗移植的替代假肢.
- 探索使用更合规的假肢用于上升性大动脉重建.
主要方法:
- 使用胸前大动脉的流体结构相互作用 (FSI) 分析创建了一个DHT.
- 开发了三种患者模型:手术前,手术后使用达克隆移植,以及手术后使用符合规定的纤维假体.
- 磁共振成像 (MRI) 数据,包括4D流MRI,用于几何重建和边界条件定义.
主要成果:
- FSI模型与4D流量数据有很好的一致性 (相对平方误差为5.28%和0.33%).
- 这两种术后情景都增加了与基线相比的壁切应力 (WSS) 和张力.
- 与达克朗移植相比,虚拟合规移植显示WSS和应变的增加较低.
结论:
- 液体结构相互作用 (FSI) 分析有助于创建可靠的胸前大动脉DHT,用于预测不同假肢的血液动力学影响.
- 更符合规定的纤维器件在上升大动脉动脉瘤修复中对远端血液动力学有中等但有前途的好处.
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