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化激素/胆性淋巴体受体多态性和辅助生殖技术结果之间的关联:系统性审查和元分析

Sha Liu, Qi Cao, Yijing Zhou

Gynecologic and obstetric investigation

|April 3, 2025

概括

黄素激素/胆性淋巴激素受体 (LHCGR) N312S多态 (rs2293275) 与辅助生殖技术 (ART) 的结果有关. 具体来说,某些基因型与提取的卵细胞数量增加和临床怀孕趋势的增加有关.

科学领域:

生殖医学生殖医学
人类遗传学人类遗传学
分子生物学分子生物学

背景情况:

化激素/胆性淋巴激素受体 (LHCGR) 基因变异与辅助生殖技术 (ART) 的成功有关.
现有的关于LHCGR基因变异与ART结果之间的关联数据是相互矛盾的.
这一元分析研究了特定的LHCGR N312S多态 (rs2293275) 以及它与ART结果的关系.

研究的目的:

澄清LHCGR N312S多态 (rs2293275) 与关键ART结果之间的关联.
提供关于这种遗传多态化及其临床相关性的现有研究的全面分析.
为了确定LHCGR N312S多态性是否可以预测ART成功.

主要方法:

在主要数据库 (PubMed,EMBASE,Web of Science,Cochrane Library) 进行了系统的文献搜索,截至2024年7月19日.
五项涉及2692名接受ART治疗的患者的研究被纳入了分析.
数据分析使用RevMan 5.4软件进行.

主要成果:

与GG (N/S) 或AG (S/S) 基因型相比,具有AA基因型 (N/N) 的个体所检索的卵细胞数量显著增加.
在基因型之间的成熟卵细胞数量中没有发现显著差异.
与A等位基因 (AA基因型) 相比,G等位基因 (存在于GG和AG基因型) 显示出临床怀孕率的上升趋势.

结论:

LHCGR N312S多态 (rs2293275) 与特定的ART结果有关,包括卵细胞检索和临床怀孕率.
这种遗传变异可能成为预测ART成功的潜在生物标志物.
需要进一步的研究,以充分阐明LHCGR在ART中的基因定型的临床实用性.

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