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Updated: May 7, 2026

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血清I型干扰素得分作为扩散性皮肤全身性硬化症患者的疾病活性生物标志物:一项回顾性队列研究

Monique Hinchcliff1, Dinesh Khanna2, Enrico De Lorenzis3

  • 1Department of Internal Medicine, Section of Rheumatology, Allergy, and Immunology, Yale School of Medicine, New Haven, CT, USA.

The Lancet. Rheumatology
|April 3, 2025
PubMed
概括

血清干扰素 (IFN) 评分可以识别患有扩散性皮肤全身性硬化症的患者,这些患者的疾病活性较高,预后更差. 这一发现有助于预测这些患者的结果和生存率.

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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