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对使用第二代抗精神病药物的儿童和青少年体重增加和代谢变化的系统审查和元分析
Suzana Figueiredo Collares1, Antônio Márcio de Ávila Júnior2, Tamires Coelho Martins2
1Master's student Program Molecular Medicine, Universidade Federal de Minas Gerais, Brazil.
Pharmacology, biochemistry, and behavior
|April 3, 2025
概括
年轻人的第二代抗精神病药与显著的体重增加和代谢问题有关. 在治疗期间,密切监测这些副作用至关重要.
科学领域:
- 儿科药理学 儿科药理学
- 代谢健康 代谢健康
- 神经科学是一个神经科学.
背景情况:
- 在儿童和青少年中增加第二代抗精神病药物的使用.
- 担心不良代谢影响,如体重增加,脂质不良和胰岛素抵抗.
- 潜在的长期健康风险包括成人肥胖和代谢综合征.
研究的目的:
- 综合目前关于SGA使用与体重增加,BMI变化和儿科患者代谢变化的相关证据.
- 提供关于这一关键问题的最新文献审查.
- 为了向临床实践提供有关青少年SGA处方的信息.
主要方法:
- 在遵守PRISMA协议的基础上进行系统审查.
- 在PROSPERO注册:CRD42024549448.8. 在PROSPERO注册:CRD42024549448. 在PROSPERO注册
- 通过使用特定关键字在MEDLINE,Scopus,Cochrane和PubMed数据库 (2024年3月) 中进行全面的文献搜索.
- 进行元分析以量化SGA与体重增加之间的关联.
主要成果:
- 体重增加,体重指数 (BMI) 增加和代谢障碍的一致发现.
- 确定的特定代谢变化包括胰岛素耐药性和腹部周长增加.
- 分析证实,至少有一个SGA与儿科患者体重增加之间存在显著的积极关联.
结论:
- 儿童和青少年使用SGA与显著的体重增加和不良代谢变化有关.
- 临床实践应包括严格的营养监测和代谢干预,以及SGA处方.
- 可能需要进一步的研究来确定特定的风险因素和缓解策略.
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