相关实验视频
Updated: Aug 10, 2026

10:33
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
20.7K
生物聚合物气凝:粉/藻酸盐网络的结构和功能定制
Marija Lucic Skoric1, Ivana Lukic2, Milica Pantic3
1Innovation Center of the Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11120 Belgrade, Serbia.
International journal of biological macromolecules
|April 3, 2025
概括
这项研究详细介绍了使用不同的溶剂交换方法和化交叉连接来制造粉/酸盐气凝. 多步骤方法产生了更高的表面积和多孔性,交叉连接显著改善了潜在的药物输送应用的机械强度.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 生物材料工程 生物材料工程
背景情况:
- 气凝为各种应用提供独特的特性.
- 粉和酸是生物相容的聚合物,有可能制造气凝.
- 控制气凝结构和特性对于目标应用至关重要.
研究的目的:
- 为了合成和表征粉/藻酸盐气凝.
- 调查制备方法 (两步与多步溶剂交换) 和化交叉连接对气凝性质的影响.
- 为了评估潜在应用的结构,机械和胀行为.
主要方法:
- 通过两步和多步溶剂交换进行气凝合成.
- 加入化 (CaCl2) 作为交叉连接剂.
- 使用FTIR,BET,SEM,机械测试和胀研究进行表征.
主要成果:
- FTIR证实了聚合物合并;BET显示表面积从4到132m2/g,多步骤方法产生更高的值.
- SEM揭示了具有多步骤交换的更加均的结构.
- 与非交叉连接的 (9 MPa) 相比,交叉连接的气凝具有显著增强的机械强度 (高达 12 MPa).
- 随着藻酸盐的含量增加,胀程度增加,交叉连接防止在PBS缓冲器中溶解.
结论:
- 制备方法和成分显著调整了粉/藻酸盐的气凝特性.
- 化交叉连接增强了机械完整性和胀控制.
- 这些可调节的气凝显示出药物输送和环境修复的前景.
相关概念视频
Carbon Skeletons
Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side chains...
Protein Folding
Overview
Protein and Protein Structure
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
A protein's shape is critical to its function. For example, an enzyme can...
Ligand Binding Sites
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Structures of Carboxylic Acid Derivatives
Structure of Carboxylic Acid Derivatives
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Carboxylic acid derivatives contain an acyl group attached to a heteroatom such as chlorine, oxygen, or nitrogen. The carbonyl carbon and oxygen are both sp2-hybridized with an unhybridized p orbital.
The three sp2 orbitals of the carbonyl carbon form three σ bonds, one each with the carbonyl oxygen, the α carbon, and the heteroatom, whereas the other two sp2 orbitals of the carbonyl oxygen are occupied by the lone pairs. Further, the unhybridized p...
Protein Folding
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...

