相关实验视频

Updated: May 16, 2025

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

在反动物的早期和晚期胎盘发育过程中,PEG10及其相互作用蛋白的进化动态

Yayi Liu¹, Wei Yu², Jiaomei Tang²

¹Hainan Institute of Northwest A&F University, Sanya 572000, China; College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China; Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Yangling 712100, Shaanxi, China.

International journal of biological macromolecules

|April 3, 2025

概括

父性表达的基因10 (PEG10) 对于反动物的胎盘发育至关重要. 这项研究揭示了PEG10

科学领域:

生殖生物学生殖生物学
遗传学遗传学是一个
哺乳动物的发展

背景情况:

动物在农业和研究中至关重要,因此了解它们的胎盘发育对于繁殖成功至关重要.
父性表达的基因10 (PEG10) 对于哺乳动物的胎盘发育至关重要,但它在反动物中的作用尚不清楚.

研究的目的:

在反动物 (牛和山羊) 中研究PEG10的基因结构和表达.
通过识别相互作用的蛋白质和途径,阐明PEG10在反动物胎盘发育中的功能.

主要方法:

跨物种对PEG10基因结构保护的分析.
对胎盘中PEG10mRNA结合能力的研究.
转录组分析以确定差异表达的基因和蛋白质-蛋白质相互作用.
相互作用蛋白质的生物信息集群和途径分析.

主要成果:

在反动物中,PEG10基因结构是保留的,它保留了结合自身mRNA的能力.
在胎盘发育的早期和晚期,PEG10表现出差异性表达.
确定了与PEG10相互作用的70种蛋白质,涉及新陈代谢,信号转导,细胞增殖和免疫.
相互作用的蛋白质与包括氨基酸降解,TCA循环和蛋白质组功能在内的途径有关.

结论:

PEG10在反动物的胎盘发育中起着重要作用.
PEG10与CAST,ITGA6和FTL等蛋白质相互作用,以调节关键的胎盘细胞过程.
这项研究提供了对控制反动物胎盘功能和发育的分子机制的见解.

关键词:

牛群是牛群,牛群是牛群,牛群是牛群.一只山羊是一只山羊.在PEG10的基础上,PEG10 胎盘胎盘胎盘胎盘蛋白质相互作用的相互作用类动物类动物

更多相关视频

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues

Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues

Published on: September 8, 2023

相关概念视频

Cleavage and Blastulation

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

Protein Modifications in the RER

Protein Modifications in the RER

Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal...