Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Urea Cycle01:23

Urea Cycle

The urea cycle describes how liver cells convert ammonia to urea. Ammonia is a toxic waste product of protein catabolism. Land animals must convert ammonia into the less toxic urea which can be safely eliminated by the kidneys through urine. Marine animals excrete ammonia directly, and the surrounding water dilutes the ammonia to safe levels.
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Corrigendum to "Nitazoxanide reverses pulmonary vascular remodeling in pulmonary hypertension by targeting the IMPA1-RAGE signaling axis" [Toxicology and Applied Pharmacology 507 (2026) 117657].

Toxicology and applied pharmacology·2026
Same author

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Severe microvascular disease incidence over a 34-year period among Chinese with newly diagnosed diabetes and impaired glucose tolerance: the Da Qing diabetes outcome study 1986-2020.

Diabetology & metabolic syndrome·2026
Same author

[Overexpressing NDUFA13 and CRIP1 improves B cell injury and lung Lesions in COPD mouse models].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2026
Same author

Small intracellular vesicle-liposome fusogenic nanoplatform sIVs-LPs@Hes: Nebulized delivery targeting pulmonary inflammatory microenvironment to improve ALI.

Materials today. Bio·2026
Same author

Multi-omics analysis identifies key genes and functional loci affecting teat number in American Large White and Landrace pigs and their application in optimizing genomic selection models.

BMC genomics·2026

相关实验视频

Updated: May 11, 2026

Glutamine Flux Imaging Using Genetically Encoded Sensors
10:23

Glutamine Flux Imaging Using Genetically Encoded Sensors

Published on: July 31, 2014

9.5K

LOX-1重新连接了谷氨胺氨基代谢,以驱动肝脏纤维化.

Ruihua Huang1, Hanyu Cui1, Mohammed Abdulaziz Yahya Ali Alshami1

  • 1Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.

Molecular metabolism
|April 3, 2025
PubMed
概括
此摘要是机器生成的。

类似莱克的氧化低密度脂蛋白受体-1 (LOX-1) 通过激活肝星细胞和改变氨代谢,促进肝纤维化. 准LOX-1为肝纤维化提供了一个有前途的治疗策略.

关键词:
在 GLS 中使用.洛克斯-1号机场肝脏纤维化 肝脏纤维化尿素循环的尿素周期

更多相关视频

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

9.1K
Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

7.6K

相关实验视频

Last Updated: May 11, 2026

Glutamine Flux Imaging Using Genetically Encoded Sensors
10:23

Glutamine Flux Imaging Using Genetically Encoded Sensors

Published on: July 31, 2014

9.5K
Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration
10:42

Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

Published on: May 13, 2016

9.1K
Cell Type-specific Gene Expression Profiling in the Mouse Liver
10:06

Cell Type-specific Gene Expression Profiling in the Mouse Liver

Published on: September 17, 2019

7.6K

科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 分子生物学分子生物学
  • 代谢性疾病 代谢性疾病

背景情况:

  • 肝纤维化是慢性肝病预后的一个关键因素.
  • 莱克类氧化低密度脂蛋白受体-1 (LOX-1) 在纤维性疾病研究中显示出潜力.
  • 对于LOX-1在肝纤维化进展中的确切作用和机制尚不完全理解.

研究的目的:

  • 为了研究LOX-1在肝纤维化进展中的作用.
  • 阐明LOX-1影响肝纤维化的潜在分子机制.
  • 探索LOX-1作为肝纤维化的潜在治疗点.

主要方法:

  • 在人类和动物肝纤维化组织中的LOX-1表达分析.
  • 在使用CCl4或MCD饮食的LOX-1淘汰老鼠中诱导肝纤维化.
  • 转录组和代谢组分析以确定LOX-1的作用机制.

主要成果:

  • 通过促进肝星细胞激活,LOX-1会加剧肝纤维化.
  • 删除LOX-1逆转了肝纤维化发展.
  • LOX-1通过谷氨酶 (GLS) 异型切换重新编程谷氨代谢,影响氨代谢和尿素循环.

结论:

  • LOX-1 在肝纤维化进展中起着关键作用.
  • LOX-1 调节肝脏氨代谢,提供新的病理洞察力.
  • 向LOX-1为抗纤维治疗提供了一个有前途的治疗策略.