自组装的贫凝,微粒聚乙烯糖醇六乙烯和静电互动的桑坦的比较稳定机制,用于水性可变乳酸乙
Sang Min Lee1, Hai Van Ngo1, Hy Dinh Nguyen1
1Department of Pharmacy, College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
International journal of pharmaceutics
|April 3, 2025
概括
这项研究使用喷雾干燥粉末在水溶液中稳定了不稳定的德西他 (DCB). 自组装的凝-油酸合物 (GOC) 纳米颗粒提供了对DCB降解的最佳保护,并控制了其释放.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 在水溶液中,由于aza-ring开放,decitabine (DCB) 的稳定性较差.
- 这种不稳定性限制了其治疗应用,需要稳定策略.
研究的目的:
- 通过使用二元喷雾干燥粉末 (SDs) 来研究水性不稳定性脱氨酸 (DCB) 的稳定机制.
- 评估自组装的等-油酸结合物 (GOC),微粒聚乙烯基醇六甲基乙 (Brij® 58) 和静电相互作用的 (XA) 的保护作用.
主要方法:
- 用GOC,Brij® 58和XA.制备DCB的二元喷雾干燥粉末 (SD).
- 在各种pH条件下评估DCB降解速率.
- 使用FE-TEM,FE-SEM,FT-IR,PXRD和DSC进行材料相互作用的表征.
- 在体外药物释放概况的评估.
主要成果:
- 中国CnC纳米颗粒显著降低了DCB降解,保护与中国CnC含量成比例增加.
- Brij® 58通过化表现出轻微的稳定作用.
- 赞坦提供了通过聚电解质复合体形成在pH4.5的稳定.
- 中国政府通过纳米化证明了最高的稳定能力.
- 中国政府的SD保持了DCB的完整性,并延迟了其释放,特别是在低pH下.
结论:
- 自组装的GOC纳米颗粒在稳定水性性脱氨酸 (DCB) 中非常有效.
- 纳米化过程和分子相互作用有助于增强DCB稳定性和受控释放.
- 喷雾干燥配方提供了一种有前途的方法,可以改善德平的稳定性和输送.
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