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移植当天的子宫内膜回声与化胚胎移植中的妊娠结果之间的关联:跨不同准备方案的回顾性队列研究

Zhao Run¹, Song Qianyan¹, Li Xiaofang²

¹Department of Reproductive Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

|April 3, 2025

概括

移植日均的子宫内膜回声显著改善了结解胚胎移植 (FET) 中的妊娠成功. 自然或GnRH主激素联合激素替代周期增强了这种统一性,这表明个性化准备方案对于更好的结果至关重要.

科学领域:

生殖医学生殖医学
胚胎转移技术的使用
不孕症治疗不孕症治疗

背景情况:

子宫内膜回声特征对于成功的胚胎植入至关重要.
优化子宫内膜受体是辅助生殖技术的关键.
了解子宫内膜制备对胚胎移植结果的影响至关重要.

研究的目的:

确定子宫内膜回声模式与冷解胚胎移植 (FET) 妊娠结果之间的关联.
评估不同子宫内膜制备方案对实现均子宫内膜回声的影响.
确定最佳的子宫内膜制备策略,以提高FET成功率.

主要方法:

对2910名接受FET治疗的患者进行了回顾性分析.
基于子宫内膜回声均性 (均与不均) 的患者分类.
在自然循环 (NC),激素替代疗法 (HRT) 和GnRH激动剂+HRT (GnRHa+HRT) 制剂组中对结果的比较.

主要成果:

一种均质的子宫内膜回声与FET中更高的临床怀孕率显著相关.
与HRT组相比,NC和GnRHa+HRT组显示出子宫内膜回声均率显著更高.
发现个性化的子宫内膜制备方案,特别是NC和GnRHa+HRT,显著改善了子宫内膜回声的一致性.

结论:

转移当天不均的子宫内膜回声与FET的临床怀孕率降低有关.
自然循环和GnRH激动剂组合激素替代方案在改善子宫内膜回声均方面是有效的.
为优化FET结果,建议根据个体患者的需求量身定制子宫内膜制备方案.

关键词:

生殖医学生殖医学回顾性研究回顾性研究亚生育能力不能生育

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