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对于Madhumukthi Kudineer Chooranum的急性和慢性毒性研究
Rajamanickam Baskar1, Govindaraju Bharathkumar2, Yovas Rajammal Manekshah3
1Department of Gunapadam (Pharmacology), Government Siddha Medical College, The Tamil Nadu Dr.MGR Medical University, Chennai, 600106, Tamil Nadu, India.
Protoplasma
|April 3, 2025
概括
马杜穆克提库迪内尔乔朗姆 (MKC) 是一种用于糖尿病的Siddha草药配方,在Sprague-Dawley大鼠中表现出极好的安全性. 毒性研究没有发现任何不良影响或死亡率,确定了高的没有观察到不良影响水平 (NOAEL).
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 草药是一种草药.
背景情况:
- 马杜穆克提库迪内尔Chooranum (MKC) 是一种用于糖尿病管理的多草药Siddha配方.
- 之前没有记录MKC的安全概况.
研究的目的:
- 为了评估Siddha草药配方MKC在Sprague-Dawley (SD) 鼠中的慢性毒性.
- 为了确定MKC的潜在治疗用途的安全性.
主要方法:
- 急性口服毒性研究:单剂量MKC (2000毫克/公斤) 给雄性和雌性SD大鼠,观察了14天.
- 慢性口服毒性研究:每天重复剂量MKC (200,400,800毫克/公斤) 给雄性和雌性SD大鼠服用180天.
- 在尸体解剖期间评估了临床症状,死亡率,体重和总体形态.
主要成果:
- 在SD大鼠中,MKC表现出卓越的耐受性,没有观察到的副作用水平 (NOAEL) 为2000 mg/kg.
- 在急性或慢性毒性试验中没有观察到任何不良反应,死亡率或参数的显著变化.
- 在研究期间,没有动物死亡或死亡.
结论:
- 在经过测试的剂量和持续时间内,MKC在斯普拉格-道利大鼠中使用是安全的.
- 该配方表现出良好的安全性,支持其在糖尿病管理中继续使用.
- 根据这些毒理学发现,可能需要进一步的临床研究.
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