在急性胰腺炎中治疗状静脉血栓的抗凝药增加了出血风险,但没有改善结果
Arpita Jajoo1, Viha Atri2, Ajaya Shrestha2
1Division of General Internal Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, United States.
在急性胰腺炎 (AP) 后,用于支架静脉血栓症 (SVT) 的抗凝血药物 (AC) 并没有减少并发症或死亡率. 在SVT患者中使用AC与显著的出血风险有关,这表明潜在的危害超过了益处.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 血管医学 血管医学
背景情况:
- 静脉血栓症 (SVT) 是急性胰腺炎 (AP) 的并发症.
- 缺乏AP中SVT的确定的治疗指南.
- 这项研究调查了抗凝血 (AC) 疗效和安全性在后AP.SVT患者.
研究的目的:
- 为了评估抗凝剂 (AC) 在治疗急性胰腺炎 (AP) 后的状静脉血栓症 (SVT) 的有效性.
- 在这个患者群体中评估AC的安全性.
- 为了确定AC是否影响与SVT相关的后果和死亡率.
主要方法:
- 从2018-2022年对AP患者的回顾性分析.
- 包括人口统计数据,临床过程,放射学发现,干预措施和结果.
- 主要结果:在AP中SVT的发展;次要结果:AC对SVT的影响.
主要成果:
- 在897名AP患者中,4.8%患有SVT,与复发性/慢性胰腺炎,恶性瘤和严重的AP过程相关.
- SVT增加了六个月死亡风险 (14%与4%相比).
- AC (在47%的SVT患者中使用) 没有预防后续 (静脉,出血,心脏病发作) 或改善存活率,但与50%的患者的出血有关.
结论:
- 在AP中,AC经常用于SVT,尽管缺乏益处的证据.
- 在SVT患者中使用AC与高出血并发症率有关.
- 目前的证据表明,AC风险可能超过AP中SVT的好处,需要进一步研究.
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