Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Phylogenetic Trees03:21

Phylogenetic Trees

45.3K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
45.3K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.1K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.1K
Phylogeny01:23

Phylogeny

43.7K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
43.7K
Translesion DNA Polymerases02:10

Translesion DNA Polymerases

9.9K
Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
9.9K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

12.5K
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
12.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Addressing the Needs of Patients With Peripheral Artery Disease Through Cardiac Rehabilitation: A Survey of Australian Cardiac Rehabilitation Programs.

Heart, lung & circulation·2026
Same author

Paired CRISPR screens identify mitochondrial metabolism and UBE2H as aneuploid-specific dependencies in human cancer cell lines.

bioRxiv : the preprint server for biology·2026
Same author

Author Correction: Titration of RAS alters senescent state and influences tumour initiation.

Nature·2026
Same author

Proteasome dysfunction underlies HERC2-linked neurodevelopmental disorder with Angelman-like clinical features.

Cell death discovery·2026
Same author

How are Leadership Skills Currently Assessed in Surgery: A Scoping Review.

Journal of surgical education·2026
Same author

Recurrent Immunogenic Neoantigens and Their Cognate T-cell Receptors in Treatment-Resistant Metastatic Prostate Cancer.

Cancer discovery·2025

相关实验视频

Updated: Jun 16, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

15.8K

DNA病变拼在一起不可能的树木.

Claudia Arnedo-Pac1, Sarah J Aitken2

  • 1Medical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.

Trends in genetics : TIG
|April 3, 2025
PubMed
概括

DNA病变可以持续多年,导致突变和体质马赛克. 这项研究揭示了它们的长期影响,即使是从发育期间的暴露.

科学领域:

  • 遗传学 遗传学 是一个
  • 分子生物学分子生物学
  • 基因组学就是基因组学.

背景情况:

  • DNA 损伤是基因组不稳定的关键因素.
  • 持续的DNA病变可能导致突变,链不对称性和体质马赛克主义.
  • 了解DNA病变的持久性对于了解长期健康影响至关重要.

研究的目的:

  • 为了研究细胞内DNA损伤持久性的持续时间.
  • 为了确定内源性DNA损伤的长期后果.
  • 探索持续性DNA病变的起源,包括子宫内暴露.

主要方法:

  • 在多个细胞周期中对DNA损伤持久性的分析.
  • 调查突变链不对称性和多基因变异.
  • 追踪来自内源性暴露的DNA病变的命运.

主要成果:

  • DNA病变可以持续很长时间,持续数月到数年.
  • 持久性病变有助于显著的遗传改变,包括体质马赛克主义.
  • 即使在子宫内,内源性暴露也可能导致长期的DNA损伤.

结论:

关键词:
造成的DNA损伤是DNA损伤.发生DNA损伤.病变分离的分离.多环系主义多环系主义突变发生的突变发生.人类遗传学是个学科.

更多相关视频

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
10:59

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

9.4K
A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.3K

相关实验视频

Last Updated: Jun 16, 2025

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

15.8K
Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
10:59

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

9.4K
A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.3K
  • DNA病变具有显著的持久性,在长时间内影响基因组完整性.
  • DNA病变的寿命长,强调了它们在慢性疾病和衰老中的潜在作用.
  • 需要进一步的研究,以充分阐明持续的DNA损伤的机制和影响.