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Updated: May 16, 2025

Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
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病原性突变会损害Hsp60在单体和小分子状态中的功能动态

Luca Torielli1, Federica Guarra1, Hao Shao2

  • 1Department of Chemistry, University of Pavia, Pavia, Italy.

Nature communications
|April 3, 2025
PubMed
概括

热冲击蛋白60 (Hsp60) 中的V72I突变使其结构刚硬,影响客户端蛋白折叠. 这项研究使用分子动力学来揭示突变如何影响Hsp60组装动力学和全调节.

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